구강안면영역에서 온도감각의 투사경로 및 처리기전
Projection pattern and processing mechanism of thermal sensation in the orofacial area
김윤숙, 배용철,
소속 상세정보
김윤숙 ( Kim Yun-Sook ) - 경북대학교 치의학전문대학원 구강해부학교실
배용철 ( Bae Yong-Chul ) - 경북대학교 치과대학 구강해부학교실
KMID : 0355820140350010001
Abstract
There is little information available about where and how the thermal sensation by heat and cold stimuli in the orofacial region is processed within the brain stem because of constraints on the experiments. However, transient receptor potential (TRP) channels stimulated by various temperatures and chemical irritant were recently cloned and their specific antibodies were generated, the research on the processing mechanism of orofacial thermal sensation in the brain stem is actively proceeding. Transient receptor potential vanilloid 1 (TRPV1) among several TRP channels is activated by noxious heat ()43°C), capsaicin, and various inflammatory mediators1’2). Transient receptor melastatin 8 (TRPM8) is stimulated by noxious and innocuous cold (〈?26C) and by menthol. Transient receptor potential ankyrin 1 (TRPA1) is activated by
noxious cold (<17°C) and pungent compounds and plays distinct roles in the cold and mechanical hypersensitivity after inflammation and neuropathic pain3_5). We here review recently published papers in our group showing that TRP channels-mediated heat and cold information is carried via specific primary afferent fibers and is processed in a distinct manner and differently in the trigeminal sensory nuclei; it provides us with useful information to understand better processing mechanisms of thermal sensation in the orofacial region.
키워드
Trigeminal; Thermal sensation; TRPA1; TRPM8; TRPVI
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